Product Information
| MW (kDa) | 14.2/28.4 |
| Purity | A greater than or equal to 95% purity was determined by SDS-PAGE. |
| Endotoxin | Endotoxin levels are less than or equal to 0.1 EU / 1 μg hVEGF-121. |
| Activity | The bioactivity of recombinant hVEGF-121 was determined in a HUVEC proliferation assay. The ED50 of each lot is less than or equal to 5 ng/mL. |
Recombinant human VEGF-121 was expressed in E. coli and is supplied in a lyophilized form.
VEGF121 is the second most abundant splice variant of vascular endothelial growth factor-A (VEGF-A; formerly VEGF) (1,2). VEGF121 is produced by endothelial cells, macrophages, T cells, and other cell types. VEGF121 is involved in angiogenesis, vascular endothelial cell survival, growth, migration, and vascular permeability (1). VEGF121 expression is induced by hypoxia, inflammatory cytokines, and through oncogene products in tumors (1-3). VEGF121 binds to VEGFR1 and VEGFR2 receptor tyrosine kinases (1). Binding of VEGF121 to VEGFR1 and VEGFR2 leads to activation of pathways involving PI3K/Akt, p38 MAPK, and FAK (1). VEGF plays a key role in tumor angiogenesis in many cancers (2).
Explore pathways related to this product.
STRING - Known and Predicted Protein-Protein Interactions.
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| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 38285S | 10 µg |
|
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