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Coming Soon: GMP-Grade Recombinant Monoclonal Antibody Conjugates for Cell Therapy Manufacturing & QC

Incorporate robust, flexible CAR-T Cell Enrichment and Detection into Your Manufacturing and QC Workflows

A graphical representation of the cell therapy manufacturing process, including steps for Cell Transduction, Cell Activation/Differentiation, Cell Expansion, Cell Enrichment, and Lot Release Testing. The last three steps are associated with solutions described on the webpage.

CST revolutionized pre-clinical CAR cell characterization with universal recombinant monoclonal antibodies specific to the ubiquitous Whitlow/218 and G4S linker sequences of scFv-based CARs. This innovation enabled scientists to use a single reagent for a variety of assays without the time or cost of developing anti-idiotype antibodies for every CAR construct.

These trusted antibody conjugates, manufactured to be GMP-grade, are intended to simplify enrichment of G4S linker CAR+ cells and increase productivity for in-process QC and lot release assays. When pre-clinical development teams use the same reagents, handoffs to clinical production can be that much easier.

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A graphical representation of scfv-expressing CAR cells with CAR linker antibodies attached to magnetic beads and attracted to a magnet for cellular enrichment.  CAR+ Cell Enrichment in Manufacturing

G4S Linker (E7O2V) Rabbit Monoclonal Antibody (Biotin Conjugate) (GMP-Grade)

  • Enrich any G4S linker-containing CAR-T cell with one reagent
  • Biotin-conjugated antibodies are amenable to magnetic bead-based CAR-T cell enrichment on cell therapy manufacturing instrumentation
  • Standardize percent CAR-positive cells and mitigate issues associated with low transduction efficiencies
  • Designed and manufactured to GMP-grade reagent standards (Full GMP certification and commercial quantities available mid-2026)
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Graphical representation of an scfv-based CAR expressed on the cell surface and attached to a CAR linker antibody labeled with a fluorophore.  CAR+ Cell Detection for Analytical QC

G4S Linker (E7O2V) Rabbit Monoclonal Antibody (PE Conjugate) (GMP-Grade)

  • Detect any G4S linker-containing CAR-T cell with one reagent
  • Simplify in-process QC and lot release assays
  • PE-conjugated antibodies plug into your existing analytical QC workflows
  • Amenable to CAR+ cell detection in flow cytometry and FACS-based enrichment
  • Designed and manufactured to GMP-grade reagent standards (Full GMP Certification & Commercial Quantities available mid-2026)
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Icon of two hands transferring an object from one hand to the other.  Seamless Transfer from Pre-Clinical to Clinical
  • Smoother handoffs when the same GMP-grade reagents are used in pre-clinical development as in manufacturing and QC
  • Save time when you don't have to qualify reagents for clinical environments
Icon of several antibody vials surrounded by circular arrows.  Reagent Security and Supply Continuity
  • Compliant GMP process and required documentation as well as controlled chain-of-custody ensure traceability
  • Recombinant monoclonal antibodies produced from a Master Cell Bank enable lot-to-lot consistency

For Research and Evaluation Use Only. Commercial GMP-Grade Reagent Availability is Anticipated in Mid-2026.

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